Construction of Genetic Relationship Matrices (GRMs)
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چکیده
Two GRMs were fitted using the method created by Zaitlen et al (2013). The first GRM comprised of pairwise relationship coefficients of all individuals in the sample. The second GRM included off-diagonal elements of pairs of individuals who has a relationship coefficient < 0.05 set to 0. Assuming inbreeding had not taken place, the second GRM excluded pairs of individuals with a most recent common ancestor of approximately four generations distant. This method has been found to account for potential upward biases due to excessive relationships which allows for the inclusion of closely and distantly related individuals in genetic analyses
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